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Investigators from the CDC and the Marshfield Clinic Research Institute, Marshfield, WI, conducted a prospective study to assess adverse events associated with a third dose of measles-mumps-rubella vaccine (MMR3). In 2017, the Advisory Committee on Immunization Practices recommended MMR3 for individuals at increased risk of mumps during an outbreak; MMR3 also may be administered for other reasons, such as lack of documentation of 2 prior doses.1 Study participants were volunteers, 18–31 years old, who had 2 documented prior doses of MMR vaccine. On the day of vaccine administration, participants were asked to report the presence of the following symptoms on a daily basis during the 14 preceding days: fever, coryza, cough, conjunctivitis, vomiting, diarrhea, jaw swelling, lymphadenopathy, …
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