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Investigators from multiple institutions conducted a randomized controlled trial comparing the effectiveness of a closed-loop system of insulin delivery (eg, artificial pancreas) to that of a standard insulin pump in maintaining target glucose levels in children with type 1 diabetes over a 16-week treatment period. Children 6-13 years old with type 1 diabetes requiring at least 10 units of insulin daily were randomized in a 3:1 manner to either the closed-loop system or the control group. For those in the closed-loop system, data transmitted from a continuous glucose monitor (CGM) to the pump were used to automatically adjust insulin delivery. Patients randomized to the control group used an insulin pump, with CGM to help determine insulin dosing. The primary study outcome was percent of …
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