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Source: Lei J, Ploner A, Elfström KM, et al. HPV vaccination and the risk of invasive cervical cancer. N Engl J Med. 2020;383(14):1340-1348; doi:10.1056/NEJMoa1
Investigators from multiple Swedish institutions conducted a registry-based cohort study to assess the association between human papillomavirus (HPV) vaccination and the risk of invasive cervical cancer. Data was obtained from the Swedish Total Population Register to identify girls and women 10-30 years old living in Sweden from 2006 to 2017. Girls and women were included if they had no previous HPV vaccination, had no previous invasive cervical cancer, and had not immigrated to Sweden after January 1, 2006.
The primary exposure was vaccination with HPV quadrivalent vaccine, as determined by ≥1 dose logged in a Swedish national vaccination registry. The age of vaccination was categorized as <17 years old and 17-30 years old. The primary outcome was occurrence of invasive cervical cancer, as determined by ICD-10 codes in the Swedish Cancer Register, a compulsory reporting …
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