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Investigators from the University of Massachusetts Medical School-Baystate conducted a retrospective study of infants with neonatal seizures to compare the efficacy of 2 antiepileptic drugs (AED) on seizure and neurodevelopmental outcomes. All neonates in the study hospital’s NICU between 2008 and 2018 who had a diagnosis of clinically identified seizures confirmed by EEG were included. Maternal antenatal and neonatal baseline clinical characteristics were obtained from the medical record, including gestational age, birth weight, 5-minute Apgar score, age at seizure onset, and etiology of seizure.
The standard protocol for neonatal seizures at the study hospital was to administer an AED intravenously for seizures confirmed by EEG. The first-line …
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