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Investigators from multiple institutions conducted a retrospective cohort study to assess the prevalence of, and risk factors for, clinically significant pediatric drug-drug interactions (cs-DDI) in hospitalized children. All hospitalizations between 2016 and 2018 involving patients <26 years of age at one of 52 children’s hospitals that contribute data to the Pediatric Health Information System (PHIS) database were included. Investigators extracted pharmacy and claims data as well as demographic, diagnosis, and length of stay from the PHIS database.
The primary exposure variable was cs-DDI, defined as 53 medication pairings (excluding medications delivered via topical, ophthalmic, and otic routes) with significant safety implications in pediatric populations as determined by an expert working group. Clinically significant …
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