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Investigators from Delhi, India, conducted a prospective observational study to assess the impact of early vs delayed administration of antibiotics on clinical outcomes in children with sepsis. Children aged 2 months to 17 years who presented to the study hospital ED between 2017 and 2019 and subsequently were admitted to the ICU for sepsis, severe sepsis, or septic shock were eligible. Sepsis was defined as Systemic Inflammatory Response Syndrome (SIRS) due to suspected infection; severe sepsis was defined as sepsis plus Acute Respiratory Distress Syndrome (ARDS) or ≥2 other organ dysfunctions; septic shock was defined as suspected infection and ≥2 of the following: decreased mental status, prolonged capillary refill, diminished or bounding peripheral …
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