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In a double-blind study, 30 children at Rhode Island Hospital with moderate to severe acute asthma exacerbations and peak expiratory flow rates (PEFR) < 70% predicted after 3 treatments with nebulized albuterol or ipratropium bromide (or both) were randomized to receive either 40 mg/kg (maximum dose 2 gm) of magnesium sulfate intravenously over 20 minutes (16 patients, 11 male, mean age 10.9 years) or normal saline (14 patients, 7 male, mean age 12 years). The children were given intravenous steroids if they had not already …
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