A Genetic Marker for Autoimmune Hepatitis

doi:10.1542/gr.6-3-29

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Source: Fainboim L, Velasco MC, Marcos C, et al. Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB1*1301, a marker for pediatric autoimmune hepatitis. Hepatology. 2001;33:1512–1517.OpenUrl CrossRef PubMed

Autoimmune hepatitis (AH) is a progressive liver disease in children and adults characterized by female predominance, elevated serum immune globulin (hypergammaglobulinemia), elevated sedimentation rate, and liver biopsy positive for fibrosis and necrosis. Type 1 AH is associated with the presence of anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA).^1,² Hepatitis A virus (HAV) has been postulated to be a potential immune trigger for AH, as the presence of auto-antibodies (anti-actin antibodies, anti-sialoglycoprotein receptor antibodies, ANA, and ASMA) have been described after HAV infection.^3,^4,⁵ AH has also been associated with HLA allele DRB1*1301 in certain South American populations.^{6, …}

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