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Autoimmune hepatitis (AH) is a progressive liver disease in children and adults characterized by female predominance, elevated serum immune globulin (hypergammaglobulinemia), elevated sedimentation rate, and liver biopsy positive for fibrosis and necrosis. Type 1 AH is associated with the presence of anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA).1,2 Hepatitis A virus (HAV) has been postulated to be a potential immune trigger for AH, as the presence of auto-antibodies (anti-actin antibodies, anti-sialoglycoprotein receptor antibodies, ANA, and ASMA) have been described after HAV infection.3,4,5 AH has also been associated with HLA allele DRB1*1301 in certain South American populations.6, …
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