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American Academy of Pediatrics
DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Overexpression of Neuropeptides and Neurotrophins in Neonatal Blood of Children with Autism or Mental Retardation

AAP Grand Rounds September 2001, 6 (3) 30; DOI: https://doi.org/10.1542/gr.6-3-30
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Source: Nelson KB, Grether JK, Crien LA, et al. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol. 2001;49:597–606.OpenUrlCrossRefPubMed

There has been little exploration of major biologic regulators of cerebral development in autism. Researchers from the National Institute of Neurological Diseases and Stroke, Genetic Disease Branch of the State of California, and UC Davis examined archived neonatal blood drawn for newborn metabolic screening to test for brain growth factors. Subjects included children with autistic spectrum disorders (n=69), mental retardation without autism (n=60), or cerebral palsy (CP, n=63) and control children (n=4).

Recycling immunoaffinity chromatography was used to measure 4 neuropeptides: substance …

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AAP Grand Rounds: 6 (3)
AAP Grand Rounds
Vol. 6, Issue 3
1 Sep 2001
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Overexpression of Neuropeptides and Neurotrophins in Neonatal Blood of Children with Autism or Mental Retardation
AAP Grand Rounds Sep 2001, 6 (3) 30; DOI: 10.1542/gr.6-3-30

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Overexpression of Neuropeptides and Neurotrophins in Neonatal Blood of Children with Autism or Mental Retardation
AAP Grand Rounds Sep 2001, 6 (3) 30; DOI: 10.1542/gr.6-3-30
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