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Survivors of childhood and adolescent cancer remain at risk for a shortened life span because of the possible long-term sequelae of cancer therapy and recurrence of the primary malignancy. These 2 excellent reports, a multi-institutional study from The Childhood Cancer Survivor Study (CCSS) in the US, and a population-based study in 5 Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden), are the largest studies to date evaluating long-term survivors of childhood cancer. The purpose of both retrospective studies was to assess the risk of death among childhood and adolescent cancer survivors.
The CCSS was a retrospectivecohort study initiated in 1994 and designed to study late effects among long-term survivors of childhood cancer. The study population consisted of a cohort of 20,227 patients who were less than 21 years of age when diagnosed with cancer between 1970 and 1986 and who survived at least 5 years beyond the date of diagnosis. Standardized mortality ratios (SMRs) were calculated based on 208,947 person-years of follow-up in …
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