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Investigators from the University of Washington evaluated the risk factors for perinatal transmission of herpes simplex virus (HSV) in a prospective multicenter study between 1982 and 1999. Viral cultures of genital secretions of enrolled pregnant women were performed within 48 hours of delivery. Maternal serologic status for HSV was determined at delivery or antepartum obstetric visit. HSV serology and culture results were used to define the type of maternal infection. Positive culture for HSV-1 or 2 without concurrent HSV antibodies was defined as primary infection; positive HSV culture and heterologous positive HSV type serology was non-primary first-episode (eg, HSV-1 isolate, HSV-2 antibodies); …
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